Dr. Swastika Ganguly

PhD M. Pharm. B. Pharm.

Date of Joining: 28th March, 2001
  • Department of Pharmaceutical Sciences, BIT, Mesra, Ranchi-835215
  • 0651-2276247
    |
    8809966752

Research Areas

  • Synthesis and Evaluation of New Chemical Entities with special reference to heterocyclic moieties :
  • Brief description of work done:
  • Various novel analogs of imidazoles, 2-methylimidazoles and 2-methyl-5-nitroimidazoles have been synthesized, characterized and evaluated for their antibacterial, antifungal, antidiarrheal, anticonvulsant and miscellaneous other activities.1- substituted imidazoles, 2-methylimidazoles and 2-methyl-5-nitroimidazoles have showed interesting activities in the field of antimycobacterial , anti fungal , anticonvulsant and antihypertensive research.
  • The benzimidazole scaffold has also been used for synthesis of novel mercaptobenzimidazoles attached to the quinazoline moiety which have been evaluated for their antiulcer activity. It is worth noting that some of the novel benzimidazoles have shown potent antiulcer activities.
  • Similarly, novel quinazolines have been synthesized which have shown very high activities against influenza virus and herpes viruses.
  • Insiilco Design, Synthesis and Evaluation of antiHIV agents.
  • Three dimensional QSAR as well as docking studies of various HIV-1- RT inhibitors, particularly non nucleoside reverse transcriptase inhibitors have been carried out. Based on the QSAR and modelling studies , various heterocyclic moieties for e.g. tetrahydroquinolines and tetrahydroisoquinolines, N-aminoimidazoles, thiazolidinediones, tetrazoles, , bernzotriazoles, and benzimidazoles have been used as scaffolds for the design and synthesis of novel analogs of these heterocycles which have been evaluated for HIV-1 -RT inhibitory activities along with antimicrobial activities to develop antiHIV agents with broad spectrum chemotherapeutic properties. Some of the N- aminoimidazole analogs have shown interesting activities against the K103N and Y181C resistant strains of HIV.
  • Encouraging results have also been found with teterahydroquinolines , tetrahydroisoquinolines and imidazoles as as dual inhibitors, exhibiting both antiHIV and antibacterial properties. Work is also being carried out in the field of HIV integrase inhibitors by modelling, synthesis and evaluation of novel diketo acids.
  • Molecular Modeling and Cheminformatics.
  • QSAR , modelling and ADMET studies using various modelling software viz., SYBYL/CoMFA and COMSIA, Schrodinger suite, FlexX, Scigress Explorer Ultra and ADME Works Model Builder for various azoles and tetrahydroquinolines have been carried out to develop predictive and robust models leading to the design of newer azoles with potential antifungal and antiHIV activities.
  • Level of already achieved success: The Principal Investigator of this proposal has been working on ‘Imidazole analogs’ since 1994. She has several collaborations with different international research laboratories and groups working in the field of anti HIV agents like Rega Institute for Medical Research, Belgium
  • Institute of Molecular Genetics , National Research Council, Italy
  • Division of Infectious Diseases, University of Pittsburgh, School of Medicine, USA
  • TAACF ,Southern Research Institute ,Birmingham, and with Developmental Therapeutics Program, NCI, NIH, USA. On a national level she has collaboration with Indian Institute of Natural Resins and Gums, Namkom, Ranchi etc. Her experience about different experiments, e.g,. synthesis of NCEs and molecular modelling etc. will be found useful for the proposed works. The PI has completed three research projects
  • one AICTE RPS project on ‘DAMNI analogs’
  • one UGC Minor Research project on “Synthesis, evaluation and molecular modelling of imidazole analogs” and one UGC Major Research Project on “In Silico Design, Synthesis and Evaluation of newer azoles as HIV-1-RT inhibitors. The PI has found very interesting results particularly with imidazole analogs against HIV-1 RT inhibitors.
  • List of Completed Sponsored Projects as PI.
  • Sl. No.
  • Title
  • Sponsor
  • Amount
  • From Date
  • To Date
  • Outcome
  • (Month-Year)
  • 1.
  • In Silico Design, Synthesis and Evaluation of newer azoles as HIV-1-RT inhibitors
  • UGC, New Delhi
  • Rs.13.838 lacs
  • 1st April 2013
  • 31st March 2016
  • 3D QSAR model was developed , anumber of newer iazoles analogs were synthesized which showed high IC50 activity against HIV-1RT
  • 2.
  • Design, Synthesis and evaluation of some DAMNI analogs as Novel NNRTIs with broad-spectrum chemotherapeutics
  • AICTE, New Delhi
  • 8.37 lacs
  • 2008
  • -2010
  • Some novel DAMNI analogs were designed and developed whch showed interesting activities against HIV -1 RT
  • 3.
  • Synthesis, Evaluation and Molecular Modeling studies of Some Imidazole analogs as potential Non Nucleoside Reverse Transcriptase Inhibitors
  • 1.40 lacs
  • 2009
  • -2011

Work Experience

  • Teaching: 21 Years
  • Research: 26 Years
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Academic Profile

Award and Honours
Award and Honours

13

Total Award and Honours
Project
Project

2

Total Project

Leadership & Institutional Service

Teaching & Mentorship

Award and Honours

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APTI(EZ) Coordinator of Women’s Forum, APTI, 2016 till date

Nominated as an Expert Member of AICTE, 2013.

THE BEST PAPER AWARD for the oral presentation entitled “Molecular Modelling of Azole antifungal agents active against Candida Albicans :A ComFA and ComSIA study”, Nanotechnology Research Centre, Kalyan, 2006

Current Sponsored Projects

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  • Study of physico-technological principles of preparation of new magnetic nanostructures `for multifunctional biomedical applications, DST, New Delhi(9 lacs, Duration: 2012-2015)(As Co-Principal Investigator)
  • In silico design, synthesis, and evaluation of newer azoles as HIV-1-RT inhibitors, UGC, New Delhi (13.83 Lacs, Duration: 2013-2016)(As Principal Investigator) Status: Completed Title: Study of physico-technological principles of preparation of new magnet

Intellectual Property Rights (IPR)

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  • Patents filed : Six Serial number Ref. no. Application Type Application Number Title/Remarks 1 ORDINARY APPLICATION 75/KOL/2012 THIAZOLIDINE-2,4-DIONE DERIVATIVES,THEIR SYNTHESIS AND USES 2. ORDINARY APPLICATION 655/KOL/2013 NOVEL THIAZOLIDINE-DIONE ANALO

    • Date:

  • Patents filed : Six

  • NOVEL THIAZOLIDINE-DIONE ANALOGS AS AN ANTIMICROBIAL AGENTS

  • ISATIN(1H-INDOLE-2,3-DIONE)DERIVATIVES,THEIR SYNTHESIS AND USES

  • NOVEL BENZIMIDAZOLES AS ANTIMICROBIALS

Fellowship

  • Fellow of Institution of Chemists